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RNA modification : ウィキペディア英語版 | RNA modification RNA modification occurs in all living organisms, and is one of the most evolutionarily conserved properties of RNAs. It can affect the activity, localization as well as stability of RNAs, and has been linked with human diseases.〔〔〔 More than 100 types of RNA modifications have been described so far, recent studies have revealed they are abundant in mRNAs and in regulatory non-coding RNAs (ncRNAs, e.g. lncRNAs, miRNAs, snoRNAs) as well as in tRNAs, rRNAs and snRNAs.〔 ==RNA Modification Technologies== To determine the transcriptome-wide landscape of RNA modifications, recently many studies have developed high-throughput modification sequencing methods to identify diverse post-transcriptional modifications of RNA molecules.〔〔〔 Application of these methods (MeRIP-seq, m6A-seq, miCLIP, m6A-CLIP/IP, Pseudo-seq, Ψ-seq, CeU-seq, Aza-IP, RiboMeth-seq) has identified various modifications (e.g. pseudouridine, m6A, m5C, 2′-O-Me) within coding genes and non-coding genes (e.g. lncRNAs, microRNAs) at single nucleotide or very high resolution.〔 A novel database, RMBase (http://mirlab.sysu.edu.cn/rmbase/),〔 has provide various web interfaces to show all RNA modification sites identified from above-mentioned sequencing technologies.
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「RNA modification」の詳細全文を読む
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